The information about how the dopamine baseline works is interesting. Those who only seek out pleasure without doing things that push themselves can become more depressed. As Huberman explained dopamine is not a pleasure chemical, it's about drive/pursuit, life-force. So if you are seeking pleasure eating ice cream and watching TV, it hurts your baseline of dopamine (drive and pursuit), and maybe you get depressed, possibly to the point you don't even feel like getting up in the morning.
But what is also interesting is that this can relate to a bigger overarching message. There are a lot of people who believe they should live life optimizing happiness, well if you don't understand how dopamine baseline works, then you would probably attempt to optimize happiness by completely avoiding the tough stuff, the "pain" activities, like working out, or studying hard, or climbing mountains, being outside in the cold, rain, etc. You might equate happiness with being comfortable/warm, relaxing on a beach, going with the flow, being mellow, etc. But in reality, you would not be optimizing happiness; you'd just be avoiding being uncomfortable in the short-term. The overarching message is that pain is a requisite for happiness, or perhaps more accurately fulfillment. The true happiness is the fulfillment you achieve by pushing yourself through something challenging, and in doing so actually increase your skills and experience, raising what you are capable of as a person. The expectation of a stable baseline of happiness "on tap" goes against physiology.